• Tanimizu N, editor. “Hepatic Stem Cells” In Methods in Molecular Biology 1905. Springer Protocols. Humana Press, 248 pages, 2019
  • Tanimizu N*, Mitaka T. “Chapter 3; Plasticity of liver epithelial cells in healthy and injured livers” In Stem Cells and Cancer in Hepatology: From the Essentials to application. 1st Edition. Yun-wen Zheng, Ed. Academic Press, pp. 35-54, 2018
  • Tanimizu N*. “Chapter 6; Development and Regeneration of Intrahepatic Bile Ducts” In Advances in Medicine and Biology. Vol. 130, Nova Science Publishers, pp. 187-216, 2018
  • Mizuguchi T, Mizuguchi T, Mitaka T, Hirata K. Role of Branched Chain Amino Acids in Cellular and Organ Damage: The prognostic significance of the preoperative branched chain amino acid to tyrosine ratio. Rajendram R, Preedy VR, Patel VB, Eds. In Branched Chain Amino Acids in Clinical Nutrition, Vol II. London: Humana Press, pp 65-77, 2015
  • Tanimizu N, Kikkawa Y, Mitaka T. “Chapter 6; Laminins: Structure, Biological Activity and Role in Disease” Demetrius C. Adams and Emil O. Garcia, eds. In Roles of laminins in epithelial morphogenesis in the liver. 2013. pp 105-116. Nova Publishers
  • Mitaka T, Sato F. “Chapter 14; Small Hepatocytes in Primary Cultures” Berry M and Edwards AM, eds. In The Hepatocyte Review, Kluwer academic publishers, Dordrecht, pp. 195-208, 2000.


* Correspondence
Bold: Equally contributed


  • Tanimizu N*, Ichinohe N, Sasaki Y, Itoh T, Sudo R, Yamaguchi T, Katsuda T, Ninomiya T, Tokino T, Ochiya T, Miyajima A, Mitaka T. Generation of functional liver organoids on combining hepatocytes and cholangiocytes with hepatobiliary connections ex vivo. Nature Communications 2021 Jun 07; 12:3390  doi: 10.1038/s41467-021-23575-1
  • Ichinohe N*, Ishii M, Tanimizu N, Mizuguchi T, Yoshioka Y, Ochiya T, Suzuki H, Mitaka T*. Extracellular vesicles containing miR-146a-5p secreted by bone marrow mesenchymal cells activate hepatocytic progenitors in regenerating rat livers.
    Stem Cell Research & Therapy, 2021 May 29;12(1):312. doi: 10.1186/s13287-021-02387-6.
  • Tanimizu N*. The neonatal liver: Normal development and response to injury and disease. Seminars in Fetal and Neonatal Medicine 2021 Mar 17:101229 doi: 10.1016/j.siny.2021.101229


International Conferences


  • Tanimizu N, Mitaka T. Studying and building liver epithelial architecture. COLD SPRING HARBOR ASIA CONFERENCES. LIVER, BIOLOGY, DISEASES & CANCER. December 8-12, 2019, Awaji, Japan.
  • Ichinohe N, Tanimizu N, Mitaka T. Transplantation of bone marrow mesenchymal cells enhance liver regeneration by secreted extracellular vesicles directly activating of hepatic progenitor cells. COLD SPRING HARBOR ASIA CONFERENCES. LIVER, BIOLOGY, DISEASES & CANCER (poster) December 8-12, 2019, Awaji, Japan.

International Conferences



  • Periods
  • Foundations
    (Project Number)
  • Principle
  • Research Project
  • 2020-2022
  • Grant-in-Aid for
    Scientific Research (C)
  • Tanimizu N
  • Research for mechanisms regulating hepato-biliary connections
  • 2019-2022
  • Grant-in-Aid for
    Scientific Research (B)
  • Sudo R
    (Mitaka T)
  • 血管相互作用を基軸にした三次元コンプレックス組織工学の創生
  • 2018-2020
  • Grant-in-Aid for
    Research (B)
  • Mitaka T
  • Research for the revival of functions in severe damaged livers by renewal of hepatocytes