Home > 研究実績 > 総説・原著論文
* Correspondence
Bold: Equally contributed


  • Tanimizu N*, Kikkawa Y, Mitaka T, Miyajima A. alpha1- and alpha5-containing laminins regulate the development of bile ducts via beta1-intergrin signals. J Biol Chem, 287(34): 28586-28597 (2012) doi: 10.1074/jbc.M112.350488
  • Senga K, Mostov K, Mitaka T, Miyajima A, Tanimizu N*. Grhl2 regulates epithelial morphogenesis by establishing functional tight junctions through the organization of a molecular network among claudin3, claudin4, and Rab25. Mol Biol Cell, 23(15): 2845-2855 (2012) doi: 10.1091/mbc.E12-02-0097
  • Takamoto T, Ichinohe N, Tabata Y*:Proliferation of Rat Mesenchymal Stem Cells in Collagen Sponges Reinforced with Poly(Ethylene Terephthalate) Fibers by Stirring Culture Method. J Biomater Sci Polym Ed, 23(13): 1741-1753 (2012) doi: 10.1163/156856211X598184
  • Shibata T, Mizuguchi T*, Nakamura Y, Kawamoto M, Meguro M, Ota S, Hirata K, Ooe H, Mitaka T. Low-dose steroid pretreatment ameliorates the transient impairment of liver regeneration. World J Gastroenterol. 18(9): 905-914 (2012) doi: 10.3748/wjg.v18.i9.905
  • Kasuya J*, Sudo R, Mitaka T, Ikeda M, Tanishita K. Spatio-temporal Control of Hepatic Stellate Cell-Endothelial Cell Interactions for Reconstruction of Liver Sinusoids in vitro. Tissue Engineer A, 18(9-10): 1045-1056 (2012) doi: 10.1089/ten.TEA.2011.0351
  • Ooe H, Chen Q, Kon J, Sasaki K, Miyoshi H, Ichinohe N, Tanimizu N, Mitaka T*. Proliferation of rat small hepatocytes depends on follistatin expression. J Cell Physiol, 227(6): 2363-2370 (2012) doi: 10.1002/jcp.22971
  • Ichinohe N, Kon J, Sasaki K, Nakamura Y, Ooe H, Tanimizu N, Mitaka T*. Growth ability and repopulation efficiency of transplanted hepatic stem, progenitor cells, and mature hepatocytes in retrorsine-treated rat livers. Cell Transplantation, 21(1): 11-22 (2012) doi: 10.3727/096368911X580626
  • Kasuya J*, Sudo R, Tamogami R, Masuda G, Mitaka T, Ikeda M, Tanishita K. Reconstruction of 3D stacked-up hepatocyte tissues by degradation of microporous poly (D,L-lactide-co-glycolide acids) membranes. Biomaterials, 33(9):2693-2700 (2012) doi: 10.1016/j.biomaterials.2011.12.039
  • Ichinohe N, Kon J, Mitaka T*. Isolation of hepatic progenitor cells from the galactosamine-treated rat liver. Methods Mol Biol, 826:49-58 (2012) doi: 10.1007/978-1-61779-468-1_5.
  • 谷水直樹三高俊広 (総説).肝上皮細胞による組織構造形成.生化学、84巻、第8号、658-665(2012)


  • Kasuya J*, Sudo R, Mitaka T, Ikeda M, Tanishita K. Hepatic stellate cell-mediated 3D tri-culture model of hepatocytes and endothelial cells. Tissue Eng A, 17(3-4): 361-370 (2011) doi: 10.1089/ten.TEA.2010.0033
  • Tanaka M*, Itoh T, Tanimizu N, Miyajima A (Review). Liver stem/progenitor cells: their characteristics and regulatory mechanisms. J Biochem. Mar; 149(3): 231-9 (2011) Review. doi: 10.1093/jb/mvr001.
  • 中村幸雄、水口徹、三高俊広、平田公一 (総説).障害肝と肝細胞移植.Surgery Frontier, 18(3), 86-89 (2011)


  • Mitaka T*, Ooe H (Review). Drug Metabolism Reviews focusing on drug transporter interactions in the liver: Characterization of hepatic-organoid cultures. Drug Metab Rev, 42(3):472-481 (2010) doi: 10.3109/03602530903492020.
  • Ichinohe N, Nakano T, Mitaka T, Umakoshi Y, Tabata Y*. Proliferation and osteogenic differentiation of rat bone-marrow stromal cells on bio-apatite with different crystalline facets. J Biomed Mat Res A, 93(2): 646-655 (2010) doi: 10.1002/jbm.a.32569
  • Mitaka T. Studies of Liver Cells: What are “small hepatocytes?” Tumor Research 45, 45-58 (2010)
  • 水口徹、中村幸雄、柴田稔人、川本雅樹、目黒誠、信岡隆幸、木村康利、古畑智久、三高俊広、平田公一 (総説).消化器外科と再生医療−肝細胞移植研究の現状と将来展望−.消化器外科、33巻3号、373-380(2010)


  • Ooe H, Kon J, Oshima H, Mitaka T*. Thyroid hormone is necessary for expression of constitutive androstane receptor in rat hepatocytes. Drug Metabol Dispos, 37(9), 1963-1969 (2009) doi: 10.1124/dmd.108.022905
  • Nobuoka T, Mizuguchi T*, Oshima H, Shibata T, Kaji S, Nagayama M, Meguro M, Mitaka T, Hirata K. Impaired liver regeneration with humoral and genetic disturbances in urinary trypsin inhibitor-deficient mice. Liver Int, 29(7), 979-87 (2009) doi: 10.1111/j.1478-3231.2009.01990.x
  • Kon J*, Ichinohe N, Ooe H, Chen Q, Sasaki K, Mitaka T*. Thy1-positive cells have bipotential ability to differentiate into hepatocytes and biliary epithelial cells in galactosamine-induced rat liver regeneration. Am J Pathol, 175(6): 2362-2371 (2009) doi: 10.2353/ajpath.2009.080338.
  • 市戸義久、今純子、大栄秀和、三高俊広 (総説).肝臓における幹細胞.肝胆膵、59巻4号、573-580(2009)


  • Sudo R*, Takahashi N, Mitaka T, Ikeda M, Tanishita K. The effect of micropatterned pores on the formation and movement of small hepatocyte colonies. J Biomech Sci Eng 3 (2): 249–262 (2008)
  • Sudo R*, Mitaka T, Ikeda M, Tanishita K. Maintenance of cell morphology and function by vertical cell-cell adhesion in three-dimensional stacked-up culture of rat hepatocyte. J Biomech Sci Eng 3 (2): 235–248 (2008)
  • Sasaki K, Kon J, Mizuguchi T, Chen Q, Ooe H, Oshima H, Hirata K, Mitaka T*. Proliferation of Hepatocyte Progenitor Cells Isolated from Adult Human livers in Serum-free Medium. Cell Transplantation, 17(10-11), 1221-1230 (2008)
  • Kikkawa Y*, Sudo R, Kon J, Mizuguchi T, Hirata K, Mitaka T. Laminin alpha 5 mediates ectopic adhesion of hepatocellular carcinoma through integrins and/or Lutheran/basal cell adhesion molecule. Exp Cell Res, 314(4), 2579-2590 (2008) doi: 10.1016/j.yexcr.2008.05.021
  • Kawasaki H, Mizuguchi T, Oshima H, Nobuoka T, Shibata T, Kaji S, Kokai Y, Katsuramaki T, Mitaka T, Hirata K. Efficient transformation of small hepatocytes into insulin-expressing cells by forced expression of Pdx1. J Hepatobiliary Pancreat Surg, 15(4), 403-409 (2008) doi: 10.1007/s00534-007-1318-2
  • Kawasaki H, Mizuguchi T*, Kikkawa Y, Oshima H, Sasaki Y, Tokino T, Kokai Y, Miyazaki J, Mitaka T, Hirata K. In vitro transformation of adult rat hepatic progenitor cells into pancreatic endocrine hormone–producing cell. J Hepatobiliary Pancreat Surg, 15(3), 310-317 (2008) doi: 10.1007/s00534-007-1252-3
  • Hashimoto W, Sudo R*, Fukasawa K, Ikeda M, Mitaka T, Tanishita K. Ductular network formation by rat biliary epithelial cells in the dynamical culture with collagen gel and dimethylsulfoxide stimulation. Am J Pathol, 173(2), 494-506 (2008) doi: 10.2353/ajpath.2008.071024
  • Oshima H, Kon J, Ooe H, Hirata K, Mitaka T*. Functional Expression of Organic Anion Transporters in Hepatic Organoids Reconstructed by Rat Small Hepatocytes. J Cell Biochem, 104(1), 68-81 (2008)
  • 三高俊広、今純子、大栄秀和、市戸義久 (総説).肝再生過程における小型肝細胞の役割.移植、43(1)、2-9 (2008)


  • Kikkawa Y*, Sasaki T, Nguyen MT, Nomizu M, Mitaka T, Miner JH. The LG1-3 tandem of laminin α5 harbors the binding sites of Lutheran/B-CAM and α3β1/α6β1 integrins. J Biol Chem, 282(20), 14853-14860 (2007)
  • Chen Q, Kon J, Ooe H, Sasaki K, Mitaka T*. Selective Proliferation of Rat Hepatocyte Progenitor Cells in Serum-free Culture. Nat Protocols, 2(5), 1197-1205 (2007)


  • Shibata C, Mizuguchi T*, Kikkawa Y, Nobuoka T, Oshima H, Kawasaki H, Kawamoto M, Katsuramaki, T, Mitaka T, Hirata K. Liver repopulation and long-term function of rat small hepatocyte transplantation as an alternative cell source for hepatocyte transplantation. Liver Transplantation, 12(1), 78-87 (2006)
  • Ooe H, Kon J, Miyamoto S, Oozone Y, Ninomiya S, Mitaka T*. Cytochrome P450 expressions of cultured rat small hepatocytes after long-term cryopreservation. Drug Metab Disposit, 34(10), 1667-1671 (2006)
  • Nobuoka T, Mizuguchi T*, Oshima H, Shibata T, Kimura Y, Mitaka T, Katsuramaki T, Hirata K. Portal blood flow regulates volume recovery of the rat liver after partial hepatectomy: Molecular evaluation. Eur Surg Res, 38(6), 522-532 (2006)
  • Nagaya M*, Kubota S, Suzuki N, Akashi K, Mitaka T. Thermoreversible gelation polymer induces the emergence of hepatic stem cells in the partially injured rat liver. Hepatology, 43(5), 1053-1062 (2006)
  • Manase K*, Endo T, Chida M, Nagasawa K, Honnma H, Yamazaki K, Kitajima Y, Goto T, Kanaya M, Hayash T, Mitaka T, Saito T. Coordinate elevation of membrane type 1-matrix metalloproteinase and matrix metalloproteinase-2 expression in rat uterus during postpartum involution. Reprod Biol Endocrinol, 4(1), 32-38 (2006)
  • Kon J*, Ooe H, Oshima H, Kikkawa Y, Mitaka T. Expression of CD44 in rat hepatic progenitor cells. J Hepatology, 45(1), 90-98 (2006)
  • 吉川大和、三高俊広 (総説).肝再生とラミニンα1鎖.Surgery Frontier, 13(2), 93-95 (2006)


  • Sudo R*, Mitaka T, Ikeda M, Tanishita K. Reconstruction of 3D stacked-up structures by rat small hepatocytes on microporous membranes. FASEB J, 19(12), 1695-1697 (2005)
  • Mizuguchi T*, Oshima H, Imaizumi H, Kohara H, Kawamoto M, Nobuoka T, Kawasaki H, Harada K, Masuda Y, Kikkawa Y, Mitaka T, Asai Y, Hirata K. Hyperbaric oxygen stimulates cell proliferation and normalized MRP2 (anion transporter) protein localization in primary rat hepatocytes. Wound Repair Regen, 13(6), 551-557 (2005)
  • Miyamoto S, Hirata K, Sugimoto S, Harada K, Mitaka T*. Expression of cytochrome P450 enzymes in hepatic organoid reconstructed by rat small hepatocytes. J. Gastroenterol. Hepatol., 20(6), 865-872 (2005)
  • Mizuguchi T*, Mitaka T, Katsuramaki T, Hirata K (Review). Hepatocyte transplantation for total liver repopulation. J Hepatobiliary Pancreat. Surg., 12(5), 378-385 (2005)
  • Sudo R*, Kohara H, Mitaka T, Ikeda M, Tanishita K. Coordinated movement of bile canalicular networks reconstructed by rat small hepatocytes. Ann Biomed Eng, 33(5), 696-708 (2005)
  • Sugimoto S, Harada K, Shiotani T, Ikeda S, Katsura N, Ikai I, Mizuguchi T, Hirata K, Yamaoka Y, Mitaka T*. Hepatic organoid formation in collagen sponge of cells isolated from human liver tissues. Tissue Eng, 11(3-4), 626-633 (2005)
  • Kikkawa Y*, Mochizuki Y, Miner JH, Mitaka T. Transient expression of laminin α1 chain in regenerating murine liver: Restricted localization of laminin chanins and nidogen-1. Exp. Cell Res., 305(1), 99-109 (2005)


  • Sudo R, Ikeda S, Sugimoto S, Harada K, Hirata K, Tanishita K, Mochizuki Y, Mitaka T*. Bile canalicular formation in hepatic organoid reconstructed by rat small hepatocytes and nonparenchymal cells. J Cell Physiol, 199(2), 252-261 (2004)
  • Nakajima-Nagata N, Sugai M, Sakurai T, Mitaka T, Katakai T, Yamato E, Miyazaki J, Tabata Y, Shimizu A*. In vitro induction of adult hepatic progenitor cells into insulin-producing cells. Biochem. Biophys. Res. Commun., 318(3), 529-534 (2004)
  • 柴田智壽、水口徹、三高俊広、平田公一 (総説).モデリングとリモデリング.Surgery Frontier, 11(2),73-75 (2004)


  • Takamura A, Adachi M*, Wada I, Mitaka T, Takayama S, Imai K. Accumulation of Hsp70/Hsc70 molecular chaperone regulator BAG-1 on COPI-coated structures in gastric epithelial cells. Internat J Oncol, 23(5), 1301-1308 (2003)
  • Ikeda S, Mitaka T*, Harada K, Sato F, Mochizuki Y, Hirata K. Tumor necrosis factor-α and IL-6 reduce bile canalicular contractions of rat hepatocytes. Surgery, 133(1), 101-109 (2003)
  • Harada K, Mitaka T*, Miyamoto S, Sugimoto S, Ikeda S, Takeda H, Mochizuki Y, Hirata K. Rapid formation of hepatic organoid in collagen sponge by rat small hepatocytes and hepatic nonparenchymal cells. J Hepatology, 39(5), 716-723 (2003)
  • 三高俊広、杉本 真一、宮本 茂樹 (総説). In Vitroにおける肝組織形成. 最新医学 58(3)、708−718 (2003)
  • 杉本真一、原田敬介、三高俊広 (総説). 肝幹細胞研究の現状 ~小型肝細胞~. 肝胆膵、46(3)、327−333 (2003)

< 前へ 次へ >