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研究業績 (*Correspondence; Bold: Equally contributed)


    1. Ichinohe N, Tanimizu N, Mitaka T*. Isolation of Small Hepatocyte-like Progenitor Cells from Retrorsine/Partial Hepatectomy Rat Livers by Laser Microdissection. Methods Mol Biol, 2544:183-193 (2022)
    2. Kino J, Ichinohe N, Ishii M, Mitaka T*. Isolation and expansion of rat hepatocytic progenitor cells. Methods Mol Biol,  1905: 29-41 (2019)  doi: 10.1007/978-1-4939-8961-4_4
    3. Ichinohe N, Kon J, Mitaka T*. Isolation of hepatic progenitor cells from the galactosamine-treated rat liver. Methods Mol Biol, 826:49-58 (2012)
    4. Okita K, Mizuguchi T, Ota S, Ishi M, Nishidate T, Ueki T, Meguro M, Kimura Y, Tanimizu N, Ichinohe N, Torigoe T, Kojima T, Mitaka T, Sato N, Sawada N, Hirata K. Pancreatic regeneration: basic research and gene regulation. Surg Today, 46(10):964-976 (2016)
    5. 市戸義久,石井雅之,谷水直樹,水口徹,平田公一,三高俊広.  組織幹細胞と組織修復 Surgery Frontier. Vol 21. No. 3, 67-69,2014
    6. 市戸義久、大栄秀和、谷水直樹、三高俊広.「各種肝病態における肝オーバル細胞・小型肝細胞の同定」再生医学叢書第5巻、第5章 肝細胞の機能制御・分化誘導」、朝倉書店、2: 102-110, 2012
    7. 三高俊広、市戸義久、谷水直樹. 肝再生における幹細胞の機能. 肝胆膵、65巻、1号、37-46、2012
    8. 市戸義久,今 純子,大栄秀和,三高俊広. 肝臓における幹細胞. 肝胆膵, 59(4), 573-580, 2009
    9. 三高俊広, 今 純子, 大栄秀和, 市戸義久. 肝再生過程における小型肝細胞の役割. 移植, 43 (1), 2-9, 2008.


      1. Ichinohe N*, Tanimizu N, Ishigami K, Yoshioka Y, Fujitani N, Ochiya T, Takahashi M, Mitaka T*. CINC-2 and miR-199a-5p in EVs secreted by transplanted Thy1+ cells activate hepatocytic progenitor cell growth in rat liver regeneration. Stem Cell Research & Therapy, 2023 14:134 https://doi.org/10.1186/s13287-023-03346-z
      2. Tanimizu N*, Ichinohe N, Mitaka T. β-adrenergic receptor agonist promotes ductular expansion during 3,5-diethoxycarbonyl-1,4-dihydrocollidine-induced chronic liver injury. Scientific Reports, 2023 May 1;13(1):7084. doi: 10.1038/s41598-023-33882-w. 
      3. Tanimizu N*, Ichinohe N, Sasaki Y, Itoh T, Sudo R, Yamaguchi T, Katsuda T, Ninomiya T, Tokino T, Ochiya T, Miyajima A, Mitaka T. Generation of functional liver tissue on combining hepatocytes and cholangiocytes with hepatobiliary connection ex vivo. Nature Communications, 2021 Jun 07; 12:3390 doi: 10.1038/s41467-021-23575-1
      4. Ichinohe N*, Ishii M, Tanimizu N, Mizuguchi T, Yoshioka Y, Ochiya T, Suzuki H, Mitaka T*. Extracellular vesicles containing miR-146a-5p secreted by transplanted bone marrow-derived mesenchymal cells activate hepatocytic progenitor cells in regenerating retrorsine-treated rat livers. Stem Cell Research & Therapy, 2021 May 29;12(1):312. doi: 10.1186/s13287-021-02387-6
      5. Tanimizu N*, Ichinohe N, Suzuki H, Mitaka T. Increased oxidative stress and delayed tissue repair exacerbate acetaminophen-induced liver injury in aged mice. Aging-US, 2020 Oct 1;12(19):18907-18927. doi: 10.18632/aging.103973
      6. Kino J, Ichinohe N, Ishii M, Suzuki H, Mizuguchi T, Tanimizu N, Mitaka T*. SelfRenewal Capability of Hepatocytic Parental Progenitor Cells Derived From Adult Rat Liver Is Maintained Long Term When Cultured on Laminin 111 in SerumFree Medium. Hepatol Commun, 2019 Nov 2; 4(1): 21-37. doi: 10.1002/hep4.1442. eCollection 2020 Jan
      7. Tanimizu N*, Ichinohe N, Mitaka T. Intrahepatic bile ducts guide formation of the hepatic nervous system in developing mouse liver. Development, Apr 25; 145(9). pii: dev159095 (2018) doi: 10.1242/dev.159095
      8. Ishii M, Kino J, Ichinohe N, Tanimizu N, Ninomiya T, Suzuki H, Mizuguchi T, Hirata K, Mitaka T*. Hepatocytic parental progenitor cells of rat small hepatocytes maintain a self-renewal capability after long-term culture. Sci Rep, Apr 11; 7: 46177 (2017) DOI: 10.1038/srep46177
      9. Tanimizu N*, Ichinohe N, Yamamoto M, Akiyama H, Nishikawa Y, Mitaka T. Progressive induction of liver progenitor cells in chronically injured liver. Sci Rep, Jan 4; 7: 39990 (2017) doi: 10.1038/srep39990
      10. Ichinohe N*, Ishii M, Tanimizu N, Kon J, Mizuguchi T, Hirata K, Mitaka T*. Transplantation of galactosamine-induced hepatic Thy1-positive cells activates the growth of intrinsic hepatic progenitor cells in retrorsine-treated rat livers. Stem Cells, 35(4): 920-931 (2017)
      11. Tanimizu N*, Ichinohe N, Ishii M, Kino J, Mizuguchi T, Hirata K, Mitaka T. Liver progenitors isolated from adult healthy mouse liver efficiently differentiate to functional hepatocytes in vitro and repopulate liver tissue. Stem Cells, 34(12):2889-2901 (2016)
      12. Tanimizu N*, Kaneko K, Itoh T, Ichinohe N, Ishii M, Mizuguchi T, Hirata K, Miyajima A, Mitaka T. Intrahepatic bile ducts are developed through formation of homogeneous continuous luminal network and its dynamic rearrangement. Hepatology, 64(1):175-188 (2016)
      13. Tanimizu N*, Kobayashi S, Ichinohe N, Mitaka T. Downregulation of miR122 by grainyhead like-2 restricts the hepatocytic differentiation potential of adult liver progenitor cells. Development, 141(23): 4448-4456 (2014)
      14. Tanimizu N, Nishikawa Y, Ichinohe N, Akiyama H, Mitaka T. Sry HMG box protein 9-positive (Sox9+) epithelial cell adhesion molecule-negative (EpCAM-) biphenotypic cells derived from hepatocytes are involved in mouse liver regeneration. J Biol Chem, Mar 14;289(11):7589-7598 (2014)
      15. Nakamura Y, Mizuguchi T, Tanimizu N, Ooe H, Ichinohe N, Hirata K, Mitaka T. Preoperative hepatocyte transplantation prevents cirrhotic rats from receiving the fatal damage by a liver resection. Cell Transplant, 23(10):1243-1254 (2014)
      16. Tanimizu N*, Nakamura Y, Ichinohe N, Mizuguchi T, Hirata K, Mitaka T. Hepatic biliary epithelial cells acquire epithelial integrity but lose plasticity to differentiate into hepatocytes in vitro during development. J Cell Sci, 126(Ppt22): 5239-5246 (2013)
      17. Ichinohe N*, Tanimizu N, Ooe H, Nakamura Y, Mizuguchi T, Hirata K, Kon J, Mitaka T*. Differentiation capacity of hepatic stem/progenitor cells isolated from d-galactosamine-treated rat livers. Hepatology, 57(3): 1192-1202 (2013)
      18. Takamoto T, Ichinohe N, Tabata Y*. Proliferation of Rat Mesenchymal Stem Cells in Collagen Sponges Reinforced with Poly(Ethylene Terephthalate) Fibers by Stirring Culture Method. J Biomater Sci Polym Ed, 23(13):1741-1753 (2012)
      19. Ooe H, Chen Q, Kon J, Sasaki K, Miyoshi H, Ichinohe N, Tanimizu N, Mitaka T. Proliferation of rat small hepatocytes requires follistatin expression. J Cell Physiol. Jun; 227(6): 2363-2370 (2012)
      20. Ichinohe N, Kon J, Sasaki K, Nakamura Y, Ooe H, Tanimizu N, Mitaka T. Growth ability and repopulation efficiency of transplanted hepatic stem cells, progenitor cells, and mature hepatocytes in retrorsine-treated rat livers. Cell Transplant 21(1): 11-22 (2012)
      21. Ichinohe N, Nakano T, Mitaka T, Umakoshi Y, Tabata Y. Proliferation and osteogenic differentiation of rat bone-marrow stromal cells on bio-apatite with different crystalline facets. J Biomed Mater Res, Part A, 93A(2): 646-655 (2010)
      22. Kon J, Ichinohe N, Ooe H, Chen Q, Sasaki K, Mitaka T. Thy1-positive cells have bipotential ability to differentiate into mature hepatocytes and biliary epithelial cells in galactosamine-induced rat liver regeneration. Am J Pathol, 175(6): 2362-2371 (2009)
      23. Ichinohe N, Kuboki Y, Tabata Y. Bone regeneration using titanium nonwoven fabrics combined with FGF-2 release from gelatin hydrogel microspheres in rabbit skull defects. Tissue Engineer Part A, 14(10): 1663-1671 (2008)
      24. Ichinohe N, Takamoto T, Tabata Y. Proliferation, osteogenic differentiation, and distribution of rat bone marrow stromal cells in nonwoven fabrics by different culture methods. Tissue Engineer Part A. 14(1): 107-116 (2008)