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研究業績 (*Correspondence)


  1. Tanimizu N*, editor. “Hepatic Stem Cells” In Methods in Molecular Biology 1905. Springer Protocols. Humana Press, 248 pages, 2019
  2. Tanimizu N*, Mitaka T. “Chapter 3; Plasticity of liver epithelial cells in healthy and injured livers” In Stem Cells and Cancer in Hepatology: From the Essentials to application. 1st Edition. Yun-wen Zheng, Ed. Academic Press, pp. 35-54, 2018
  3. Tanimizu N*. “Chapter 6; Development and Regeneration of Intrahepatic Bile Ducts” In Advances in Medicine and Biology. Vol. 130, Nova Science Publishers, pp. 187-216, 2018
  4. Tanimizu N*, Kikkawa Y, Mitaka T. “Chapter 6; Laminins: Structure, Biological Activity and Role in Disease” Demetrius C. Adams and Emil O. Garcia, eds. In Roles of laminins in epithelial morphogenesis in the liver. 2013. pp 105-116. Nova Publishers
  5. 市戸義久、大栄秀和、谷水直樹、三高俊広.「各種肝病態における肝オーバル細胞・小型肝細胞の同定」再生医学叢書第5巻、第5章 肝細胞の機能制御・分化誘導」、朝倉書店、2: 102-110, 2012


  1. Tanimizu N*. The neonatal liver: Normal development and response to injury and disease. Seminars in Fetal and Neonatal Medicine, in press (2021) doi: 10.1016/j.siny.2021.101229
  2. Tanimizu N*, Mitaka T. Epithelial morphogenesis during liver development. Cold Spring Harb Perspect Biol, eb 17; pil: a027862 (2017). doi: 10.1101/cshperspect.a027862
  3. Tanimizu N*, Mitaka T. Which is better source for functional hepatocytes? (Editorial) Stem Cell Invest, 4:12 (2017) doi: 10.21037/sci.2017.02.08
  4. Tanimizu N*, Mitaka T. Morphogenesis of Liver Epithelial Cells. Hepatol Res, 46(10): 964-976 (2016) doi: 10.1111/hepr.12654
  5. Tanimizu, N*. Clonal culture of mouse liver progenitor cells. Bioprotocol, 5: 1-7 (2015)
  6. Okita K, Mizuguchi T, Ota S, Ishi M, Nishidate T, Ueki T, Meguro M, Kimura Y, Tanimizu N, Ichinohe N, Torigoe T, Kojima T, Mitaka T, Sato N, Sawada N, Hirata K. Pancreatic regeneration: basic research and gene regulation. Surg Today, 2016 Jun; 46(6): 633-640. doi: 10.1007/s00595-015-1215-2.
  7. Tanimizu N*, Mitaka T. Reevaluation of cell supply from liver stem/progenitor cells and the lineage conversion during liver development and regeneration. Organogenesis, 10(2); 208-215 (2014) doi: 10.4161/org.27591
  8. Tanimizu N*, Mitaka T. Role of Grainyhead-like 2 in the formation of functional tight junctions. Tissue Barriers (Commentaries), 1(1): e23495s (2013) doi: 10.4161/tisb.23495
  9. 谷水直樹、宮島篤 (総説).胆管の発生と制御機構.肝胆膵、65巻、1号、73−82 (2012)
  10. 谷水直樹、三高俊広.肝上皮細胞による組織構造形成.生化学、84巻、第8号、658-665 (2012)
  11. Tanaka M*, Itoh T, Tanimizu N, Miyajima A. Liver stem/progenitor cells: their characteristics and regulatory mechanisms. J Biochem, 149(3): 231-239 (2011)
  12. Tanimizu, N*, Miyajima, A. Molecular Mechinism of liver development and regeneration. Review of Cytology 259, 1-48 (2007)


    1. Tanimizu N*, Ichinohe N, Sasaki Y, Itoh T, Sudo R, Yamaguchi T, Katsuda T, Ninomiya T, Tokino T, Ochiya T, Miyajima A, Mitaka T. Generation of functional liver tissue on combining hepatocytes and cholangiocytes with hepatobiliary connection ex vivo. Nature Communications,2021 Jun 07; 12:3390 doi: 10.1038/s41467-021-23575-1
    2. Ichinohe N*, Ishii M, Tanimizu N, Mizuguchi T, Yoshioka Y, Ochiya T, Suzuki H, Mitaka T*. Extracellular vesicles containing miR-146a-5p secreted by transplanted bone marrow-derived mesenchymal cells activate hepatocytic progenitor cells in regenerating retrorsine-treated rat livers. Stem Cell Research & Therapy, 2021 May 29;12(1):312. doi: 10.1186/s13287-021-02387-6
    3. Tanimizu N*, Ichinohe N, Suzuki H, Mitaka T. Increased oxidative stress and delayed tissue repair exacerbate acetaminophen-induced liver injury in aged mice. Aging-US, 2020 Oct 1;12(19):18907-18927. doi: 10.18632/aging.103973
    4. Kino J, Ichinohe N, Ishii M, Suzuki H, Mizuguchi T, Tanimizu N, Mitaka T*. SelfRenewal Capability of Hepatocytic Parental Progenitor Cells Derived From Adult Rat Liver Is Maintained Long Term When Cultured on Laminin 111 in SerumFree Medium. Hepatol Commun, 2019 Nov 2; 4(1): 21-37. doi: 10.1002/hep4.1442. eCollection 2020 Jan
    5. Tanimizu N*. Isolation of bipotential liver progenitor cells from neonatal mouse liver. Methods Mol Biol1905: 9-17 (2019) doi: 10.1007/978-1-4939-8961-4_2
    6. Tanimizu N*. Identification and in vitro expansion of adult hepatocyte progenitors from chronically injured liver. Methods Mol Biol, 1940:267-273(2019) doi: 10.1007/978-1-4939-9086-3_19
    7. Tanimizu N*, Ichinohe N, Mitaka T. Intrahepatic bile ducts guide formation of the hepatic nervous system in developing mouse liver. Development, Apr 25; 145(9). pii: dev159095 (2018) doi: 10.1242/dev.159095
    8. Ishii M, Kino J, Ichinohe N, Tanimizu N, Ninomiya T, Suzuki H, Mizuguchi T, Hirata K, Mitaka T*. Hepatocytic parental progenitor cells of rat small hepatocytes maintain a self-renewal capability after long-term culture. Sci Rep, Apr 11; 7: 46177 (2017) DOI: 10.1038/srep46177
    9. Tanimizu N*, Ichinohe N, Yamamoto M, Akiyama H, Nishikawa Y, Mitaka T. Progressive induction of liver progenitor cells in chronically injured liver. Sci Rep, Jan 4; 7: 39990 (2017) doi: 10.1038/srep39990
    10. Ichinohe N*, Ishii M, Tanimizu N, Kon J, Mizuguchi T, Hirata K, Mitaka T*. Transplantation of galactosamine-induced hepatic Thy1-positive cells activates the growth of intrinsic hepatic progenitor cells in retrorsine-treated rat livers. Stem Cells, 35(4): 920-931 (2017) doi: 10.1002/stem.2548
    11. Tanimizu N*, Ichinohe N, Ishii M, Kino J, Mizuguchi T, Hirata K, Mitaka T. Liver progenitors isolated from adult healthy mouse liver efficiently differentiate to functional hepatocytes in vitro and repopulate liver tissue. Stem Cells, 34(12): 2889-2901 (2016) doi: 10.1002/stem.2457
    12. Tanimizu N*, Kaneko K, Itoh T, Ichinohe N, Ishii M, Mizuguchi T, Hirata K, Miyajima A, Mitaka T. Intrahepatic bile ducts are developed through formation of homogeneous continuous luminal network and its dynamic rearrangement. Hepatology, 64(1):175-188 (2016) doi: 10.1002/hep.28521
    13. Tanimizu N*. Clonal culture of mouse liver progenitor cells. Bioprotocol, 5: 1-7 (2015)
    14. Tanimizu N*, Kobayashi S, Ichinohe N, Mitaka T. Downregulation of miR122 by grainyhead like-2 restricts the hepatocytic differentiation potential of adult liver progenitor cells. Development, 141(23): 4448-4456 (2014) doi: 10.1242/dev.113654
    15. Tanimizu N, Nishikawa Y, Ichinohe N, Akiyama H, Mitaka T. Sry HMG box protein 9-positive (Sox9+) epithelial cell adhesion molecule-negative (EpCAM-) biphenotypic cells derived from hepatocytes are involved in mouse liver regeneration. J Biol Chem, 289(11): 7589-7598 (2014) doi: 10.1074/jbc.M113.517243
    16. Nakamura Y, Mizuguchi T, Tanimizu N, Ooe H, Ichinohe N, Hirata K, Mitaka T. Preoperative hepatocyte transplantation prevents cirrhotic rats from receiving the fatal damage by a liver resection. Cell Transplant, 23(10): 1243-1254 (2014) doi: 10.3727/096368913X668645
    17. Tanimizu N*, Nakamura Y, Ichinohe N, Mizuguchi T, Hirata K, Mitaka T. Hepatic biliary epithelial cells acquire epithelial integrity but lose plasticity to differentiate into hepatocytes in vitro during development. J Cell Sci, 126(Ppt22): 5239-5246 (2013) doi: 10.1242/jcs.133082
    18. Kiyohashi K, Kakinuma S*, Kamiya A, Sakamoto N, Nitta S, Yamanaka H, Yoshino K, Fijuki J, Murakawa M, Kusano-Kitazume A, Shimizu H, Okamoto R, Azuma S, Nakagawa M, Asahina Y, Tanimizu N, Kikuchi A, Nakauchi H, Watanabe M. Wnt5a signaling mediates biliary differentiation of fetal hepatic stem/progenitor cells. Hepatology, 57(6): 2502-2513 (2013)
    19. Ichinohe N*, Tanimizu N, Ooe H, Nakamura Y, Mizuguchi T, Hirata K, Kon J, Mitaka T*. Differentiation capacity of hepatic stem/progenitor cells isolated from d-galactosamine-treated rat livers. Hepatology, 57(3): 1192-1202 (2013) doi: 10.1002/hep.26084
    20. Tanimizu N*, Kikkawa Y, Mitaka T, Miyajima A. alpha1- and alpha5-containing laminins regulate the development of bile ducts via beta1-intergrin signals. J Biol Chem, 287(34): 28586-28597 (2012) doi: 10.1074/jbc.M112.350488
    21. Senga K, Mostov K, Mitaka T, Miyajima A, Tanimizu N*. Grhl2 regulates epithelial morphogenesis by establishing functional tight junctions through the organization of a molecular network among claudin3, claudin4, and Rab25. Mol Biol Cell, 23(15): 2845-2855 (2012) doi: 10.1091/mbc.E12-02-0097
    22. Ooe H, Chen Q, Kon J, Sasaki K, Miyoshi H, Ichinohe N, Tanimizu N, Mitaka T. Proliferation of rat small hepatocytes requires follistatin expression. J Cell Physiol. Jun; 227(6): 2363-2370 (2012) doi: 10.1002/jcp.22971
    23. Ichinohe N, Kon J, Sasaki K, Nakamura Y, Ooe H, Tanimizu N, Mitaka T. Growth ability and repopulation efficiency of transplanted hepatic stem cells, progenitor cells, and mature hepatocytes in retrorsine-treated rat livers. Cell Transplant 21(1): 11-22 (2012) doi: 10.3727/096368911X580626
    24. Tanimizu N, Miyajima A, Mostov K. Liver progenitor cells fold up a cell monolayer into a double-layered structure during tubular morphogenesis. Mol Biol Cell 20, 2486-2494 (2009)
    25. Tanimizu N, Miyajima A, Mostov K. Liver progenitor cells develop cholangiocyte-type epithelial polarity in three dimensional culture. Mol Biol Cell 18, 1472-1479 (2007)
    26. Tanimizu N, Saito H., Mostov K, Miyajima A. Long-term culture of hepatic progenitors derived from mouse Dlk+ hepatoblasts. J Cell Sci. 117, 6425-6434 (2004)
    27. Tanimizu N, Tsujimura T, Takahide K, Kodama T, Nakamura K, Miyajima A. (2004) Expression of Dlk/Pref-1 defines a subpopulation in the oval cell compartment of rat liver. Gene Expr Patterns 5, 209-218.
    28. Tanimizu N, Miyajima A. Notch signaling controls hepatoblasts differentiation by alternating the expression of liver-enriched transcription factors. J Cell Sci, 117, 3165-3174 (2004)
    29. Tanimizu N, Nishikawa M, Saito H, Tsujimura T, Miyajima A. Isolation of hepatoblasts based on expression of Dlk/Pref-1. J Cell Sci. 116, 1775-1786 (2003)
    30. Tanimizu N, Ueno H, Hayashi R. Replacement of His12 or His119 of bovine pancreatic ribonuclease A with acidic amino acid residues for the modification of activity and stability. J Biosci.Bioeng. 94, 39-44 (2002)
    31. Tanimizu N, Ueno H, Hayashi R. Role of Phe120 in the activity and structure of bovine pancreatic ribonucleae A. J Biochem. 124, 410-416 (1998).
    32. Tanimizu, N. and Hayashi, R. Change in vascular protease activities during synchronous culture of Saccharomyces cerevisiae. Biotechnol Biochem, 60, 1526-1527 (1996)